Fig. 7

Persistent effects of WBH on behavioural deficits in the C58 mice. Timeline of the whole-body hyperthermia protocol and the behavioural tasks is as per Fig. 6F. The heating chamber was set to 33.5 °C to reach the target body temperature of 39.5 °C. A Effects of WBH in C58 strain on positive symptoms, over 48 h, represented by upright scrabbles and backflips. B Effect of WBH on locomotor activity as measured by mean speed and number of rotations. C Effect of WBH on social interaction as measured by frequency of sniffs and time spent sniffing an unfamiliar conspecific. All data are presented as mean ± SEM (n = 12 for WBH and 11 for RT) and * and ** denote p < 0.05 and p < 0.01, respectively, for Fisher’s LSD post hoc comparisons of WBH vs. RT after significant main effects of treatment or time by repeated measures two-way ANOVA