Fig. 2

Inflammatory markers at 4 h post-whole-body hyperthermia (WBH) or LPS. A Peripheral blood cytokines measured at 4 h after the WBH protocol: IL-1β, IL-6 and TNF-α levels (pg/ml). B mRNA expression of brain cytokines and inflammatory markers in brain homogenates of hypothalamus, hippocampus and amygdala. Data are shown as mean ± SEM, with each data point representing one animal (n = 5 for WBH and n = 4 for LPS, RT). Data have been analysed by parametric or nonparametric statistics as appropriate to the data distribution: Kruskal–Wallis or one-way ANOVA followed by Mann–Whitney or Bonferroni’s tests p < 0.05. (* LPS vs. RT; # WBH vs. LPS). Abbreviations: RT room temperature; LPS intraperitoneally injected lipopolysaccharide, 250 µg/kg; WBH whole-body hyperthermia