Fig. 5

Locomotion kinematics are altered in the neurodevelopmental mouse models. a Stacked bar plots showing the mean frequency for each of four speed bins on Days 1 through 4. b Left: Examples of the motion of the limb and tail points during 5-s bouts of locomotion for C57BL/6J, Cntnap2 KO and L7-Tsc1 mutants. The trajectory of the centroid of the mouse is color coded by time. Time series of the position of each body part projected onto the anterior–posterior axis is plotted. The start of each gait cycle is marked with a dashed black line and defined using the front right paw (FR, red). Center: An example image of a mouse is labeled with colors used for each body part, and the axis of body alignment used when segmenting strides is shown as the axis between the nose and tail base point (TP). Right: Polar plots of the phase \(\theta\) of the gait cycle in which each paw reaches a minimum along the alignment axis in the body frame. The front right paw is used to define \(\theta =0\). The radial axis indicates the speed of locomotion, which was used to bin the phase results, and the size of the circles indicate how frequent that particular speed was for a given condition. For Cntnap2 KO and L7-Tsc1 mutants, the colors of dots correspond to the four labeled paw points