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Fig. 4 | Molecular Autism

Fig. 4

From: Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism

Fig. 4

Replication of hiPSC-neuron RNA-seq. A replication set of hiPSC-neurons collected at 6 weeks in culture were subjected to RNA-seq. a Correlation coefficients between samples from the same donor and same clone (technical replicates), same clone but different induction (biological replicates), and correlations between all other samples. A Wilcoxon rank-sum test was used to test for differences between the means of correlation coefficients. b The second replication batch of hiPSC-neurons were used to derive differential gene expression signatures between PMS probands and unaffected siblings. The PMS-associated log2 fold-changes from this replication set (x-axis) were compared to PMS-associated log2 fold-changes from the discovery set of samples, which were derived using combinations technical replicates and biological replicates at different weeks in culture (y-axis)

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Molecular Autism

ISSN: 2040-2392