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Fig. 2 | Molecular Autism

Fig. 2

From: Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism

Fig. 2

Genes and pathways associated with PMS. Differential gene expression analyses adjusted for sequencing batch, biological sex, RIN, and individual donor as a repeated measure using the dupCorrelation function in the limma R package. Volcano plots compare the extent of PMS-associated log2 fold-changes to -log10 multiple test corrected p value in a hiPSC-NPCs and b hiPSC-neurons. Black dotted line indicates genes passing an adjusted p < 0.05. c Genome-wide concordance of PMS-associated log2 fold-changes was examined between hiPSC-NPCs and hiPSC-neurons. Inset Venn diagram displays the overlap of significant differentially expressed genes between the two cell types. Functional enrichment analysis of PMS dysregulated genes that show d under-expression in hiPSC-NPCs, e under-expression in hiPSC-neurons, and f over-expression in hiPSC-neurons. All enrichment terms displayed pass a multiple test corrected p value. g Log2 fold-change plot of significantly under-expressed genes in PMS and their respective gene ontology term. Abbreviations: Reg of Wnt, regulation of Wnt signaling; ECM, extracellular matrix

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Molecular Autism

ISSN: 2040-2392