Table 1 Cohort characteristics
Patient | Age | Sex | TIQ | Gene | Mutation | Epilepsy | Seizure control1 | Medication | Psychiatric diagnoses2 |
|---|---|---|---|---|---|---|---|---|---|
1 | 8.3 | M | 82 | TSC-2 | De novo | Focal (M) | Yes | VPA, OXC | – |
2 | 9.4 | F | <40 | TSC-2 | De novo | Focal (N-M) | No | VPA, LTG, VGB | ASD |
3 | 9.5 | M | 107 | TSC-1 | Familial | No | NA | NA | ASD |
4 | 10.1 | M | <40 | TSC-2 | De novo | Focal (M) | No | VPA, FBM | ASD |
5 | 10.7 | M | 107 | NMI | NA | Focal (M) | Yes | OXC | – |
6 | 11.2 | M | 47 | TSC-2 | Familial | Focal (M) | Yes | VPA | ASD |
7 | 11.8 | F | 80 | TSC-1 | Familial | No | NA | NA | ASD |
- | 12.6 | M | 49 | NMI | NA | Focal (M) | Yes | LEV, RAM | – |
8 | 13.7 | F | 88 | TSC-1 | Familial | CR | NA | NA | – |
9 | 13.8 | F | 51 | NT | NA | Focal (M) | No | OXC | ADD, MD |
- | 14.0 | F | 63 | TSC-2 | De novo | Focal (M) | Yes | OXC | Selective mutism |
10 | 14.4 | M | <40 | TSC-2 | De novo | Focal (N-M) | No | VPA | ASD |
11 | 16.3 | F | 70 | TSC-2 | De novo | No | NA | ESC | ASD, MD |
12 | 17.6 | F | 88 | TSC-2 | Familial | No | NA | ESC | Anxiety, MD |
13 | 21.3 | M | 49 | TSC-2 | De novo | Focal (M) | No | LEV | – |