Strain | Source and background | First citation | Behavioral phenotype | Synaptic proteins | Electrophysiology |
---|---|---|---|---|---|
Shank3B−/− | Jax #017688 C57BL/6J | [27] | Abnormal social behavior; excessive grooming leading to self-injury. | Reduced PSD levels of GluR2, NR2A/2B, Homer. | In striatum: reduced mEPSP frequency and amplitude; reduced population spike amplitude. |
Shank3Δex4–9+/− | Jax #017890 C57BL/6J | [28] | Less social sniffing, fewer vocalizations in males exposed to females. | Reduced GluR1 immunofluorescent puncta in hippocampus. | In hippocampus: reduced mEPSP amplitude but increased frequency. AMPAR-dependent deficit in population spike amplitude. Impaired LTP, normal LTD. |
Ube3a2xTG | Jax #017482 FVB | [34] | Abnormal social behavior, fewer ultrasonic vocalizations in adult animals, increased repetitive grooming | Reduced ARC levels. | In whisker barrel cortex: reduced mEPSP frequency and amplitude; reduced evoked EPSC amplitude. |
Cntnap2-/- | Jax #017482 C57BL/6J | Abnormal social behavior, fewer pup ultrasonic vocalizations, increased repetitive grooming | Â | Somatosensory cortex: reduced population synchronization by Ca2+ imaging. | |
TSC2+/− | Jax #004686 B6129SF2/J | [65] | Abnormal social behavior [63], impaired hippocampal-dependent memory [37]. Abnormal pup vocalizations [66] | Hippocampus: increased mGluR5 [67]. | Hippocampus: enhanced LTP [37], reduced LTD in juveniles, abnormal but present LTD in adults [67]. |
FMR−/y | Jax #003025 C57BL/6 J | [68] | Abnormal social behavior, increased repetitive behaviors, impaired memory; reviewed in [69]. | Less mGluR5 in forebrain PSD preps; normal levels of other GluRs; normal levels of all receptors in total membrane lysates. [70]. | Hippocampus: enhanced, abnormal LTD; LTP reported impaired or normal (reviewed by [69]). Cortex: normal LTP at 2 months, abnormal at 12 months [71]. |
VPA | Generated by M. Fahnestock, McMaster U. CD-1 | Reduced social interaction, increased repetitive/stereotyped behaviors [73], reduced vocalizations [74], | Cortex of 2-week-old rats: increased NR2A/B, [35]; adult rats: reduced PSD95 [52]. | Cortical pyramidal neurons: enhanced NMDAR-mediated currents, enhanced LTP [35]. |