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Table 2 Glycation, oxidation, and nitration adduct residue content of plasma protein

From: Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism - a source of biomarkers for clinical diagnosis

Glycation markers

Healthy controls

ASD

P value

FL (mmol/mol lys)

1.27 ± 0.39

1.41 ± 0.53

NS

CML (mmol/mol lys)

0.158 ± 0.026

0.190 ± 0.038

0.0018*

CEL (mmol/mol lys)

0.117 ± 0.044

0.092 ± 0.054

NS

G-H1 (mmol/mol arg)

0.012 ± 0.005

0.016 ± 0.011

NS

MG-H1 (mmol/mol arg)

0.473 ± 0.074

0.535 ± 0.100

0.021

3DG-H (mmol/mol arg)

0.165 ± 0.037

0.138 ± 0.027

0.0052

CMA (mmol/mol arg)

0.054 (0.043–0.067)

0.077 (0.066–0.101)

0.000082**

MOLD (mmol/mol lys)

0.027 ± 0.011

0.025 ± 0.016

NS

GSP (mmol/mol lys)

0.514 ± 0.111

0.571 ± 0.206

NS

DT (mmol/mol tyr)

0.025 (0.019–0.031)

0.047 (0.035–0.094)

0.000012***

NFK (mmol/mol trp)

15.6 ± 1.7

15.0 ± 1.5

NS

AASA (mmol/mol lys)

0.154 ± 0.048

0.152 ± 0.081

NS

GSA (mmol/mol arg)

0.639 ± 0.327

0.713 ± 0.350

NS

3-NT (mmol/mol tyr)

0.0056 (0.0045–0.0069)

0.0053 (0.0045–0.0064)

NS

  1. Data are median (lower–upper quartile); healthy controls, n = 21, and ASD, n = 27. Significance (Mann–Whitney U)
  2. *P < 0.05, **P < 0.01, and ***P < 0.001 after Bonferroni correction of 14 applied