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Table 3 Correlation of RORA and target gene expression in the orbital frontal cortex (OFC) of age-matched females and males

From: Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism

A2BP1 vs. RORA

Females

Males

Group (no. of samples)

F_BB (6)

F_0-18 (3)

F >19 (3)

M_BB (5)

M_0-18 (3)

M >19 (3)

Correlation coefficient

-0.68

0.99

0.35

-0.39

0.73

-0.99

P val (2-tailed)

0.13

0.08

0.77

0.51

0.48

0.09

R2

0.47

0.98

0.12

0.15

0.54

0.99

ITPR1 vs. RORA

Females

Males

Group (no. of samples)

F_BB (6)

F_0-18 (3)

F >19 (3)

M_BB (5)

M_0-18 (3)

M >19 (3)

Correlation coefficient

0.36

0.99

0.72

0.29

0.96

-0.76

P val (2-tailed)

0.49

0.10

0.49

0.64

0.18

0.45

R2

0.14

0.97

0.52

0.08

0.92

0.54

NLGN1 vs. RORA

Females

Males

Group (no. of samples)

F_BB (6)

F_0-18 (3)

F >19 (3)

M_BB (5)

M_0-18 (3)

M >19 (3)

Correlation coefficient

-0.26

0.97

1.00

−0.52

-0.03

0.95

P val (2-tailed)

0.61

0.16

0.02

0.37

0.98

0.21

R2

0.08

0.93

1.00

0.27

0.00

0.90

  1. The correlation coefficients, P values, and R2 values are shown for RORA expression and that of A2BP1, ITPR1, and NLGN1 across each of the three developmental periods.