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Table 1 Genes showing >2fold change at P < 0.05 in 39,X Y* O whole brain based on the microarray analysis

From: Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder

Upregulated in 39,XY*O brain

Gene

Chromosome

Product

Fold change

P-value

Human orthologue

Gm16432

1

Function unknown

5.5

0.006

None

Vmn2r86

10

Vomeronasal 2 receptor 86

3.6

0.03

None

Sfi1

11

Sfi1 homolog, spindle assembly associated (yeast)

3.3

0.007

SFI1 (22q12.2)

Pisd-ps1

11

Phosphatidylserine decarboxylase, pseudogene 1

2.7

0.02

None

Tagap1

17

T cell activation GTPase activating protein 1

2.4

0.01

None

C1qc

4

Complement component 1, q subcomponent, C chain

2.3

0.002

C1QC (1p36.11)

Fam177a

12

Family with sequence similarity 177, member A

2.2

0.004

FAM177A1 (14q13.2)

Metap1d

2

Methionyl aminopeptidase type 1D

2.0

0.0003

METAP1D (2q31.1)

Downregulated in 39,X Y* O brain

Gene

Chromosome

Product

Fold change

p-value

Human orthologue

Erdr1

Y

Erythroid differentiation regulator 1

3.6

1.3x10−6

None

Trdn

10

Triadin

3.1

0.03

TRDN (6q22.31)

Gm12696

4

Pseudogenic RNA

2.9

0.01

None

Fut11

14

Fucosyltransferase 11

2.2

0.002

FUT11 (10q22.2)

AA388235

17

Non-coding RNA

2.1

0.03

None