Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder

Table 2 Top five biological functions, disorders, and canonical pathways associated with 2,544 potential transcriptional targets of RORA

Biological functions, disorders, and pathways	P value	Number of molecules
Physiological system development and function
Organismal survival	3.56E-08 to 6.82E-04	305
Nervous system development and function	5.83E-08 to 4.28E-03	344
Tissue morphology	5.83E-08 to 4.72E-03	419
Cardiovascular system development and function	8.89E-08 to 4.72E-03	268
Embryonic development	9.01E-08 to 4.72E-03	370
Diseases and disorders
Hereditary disorder	8.09E-06 to 1.56E-03	204
Neurological disease	8.09E-06 to 4.72E-03	292
Psychological disorders	8.09E-06 to 8.09E-06	107
Cancer	1.65E-05 to 4.77E-03	731
Hematological disease	1.65E-05 to 4.67E-03	166
Top canonical pathways		Ratio
Superpathway of inositol phosphate compounds	4.97E-04	37/227
Production of nitric oxide and reactive oxygen species in macrophages	1.29E-03	35/210
Axonal guidance signaling	2.47E-03	69/468
3-phosphoinositide biosynthesis	2.52E-03	29/175
Small cell lung cancer signaling	2.60E-03	17/89

These data were obtained using Ingenuity Pathway Analysis software. P values were calculated using Fisher's exact test, which was performed using the entire set of genes within the Ingenuity Knowledge Base as the reference set.

ISSN: 2040-2392