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Fig. 9 | Molecular Autism

Fig. 9

From: Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

Fig. 9

Theta and gamma phase preferences of CA1 pyramidal neurons differ between WT and Fmr1−/y rats. A Schematic depiction of oscillation phases. The oscillation troughs were defined as 0°. B Mean preferred theta phase for significantly phase-locked (Rayleigh p < 0.05) CA1 pyramidal neurons during the six recording sessions. Fmr1−/y neurons fired during the ascending phase of theta on both days, whereas WT neurons fired significantly earlier (at the trough of theta) on Day 1, and shifted to the ascending phase of theta on Day 2 (Harrison-Kanji test: main effect of genotype p < 0.001; genotype x day interaction p = 0.0025; Watson-Williams post hoc tests Day 1 vs Day 2: WT p < 0.001, Fmr1−/y p > 0.05; WT vs Fmr1−/y: Day 1 *p < 0.001, Day 2 *p < 0.001). C Distribution of preferred theta phase for unique pyramidal neurons recorded from WT (Top-black) and Fmr1−/y (Bottom-red) rats during Day 1 (left) and Day 2 (right). D Same as (B) for slow gamma phase. Fmr1−/y pyramidal neurons fired earlier during the descending phase of the oscillation compared to WT (Harrison-Kanji test: main effect of genotype: p = 0.003) (Watson-Williams post hoc tests, Day 1 *p < 0.05; Day 2 p = 0.103). This effect was driven by differences between genotypes during Day 1 (). E Same as (C) for slow gamma oscillations. F Same as (B) for medium gamma phase. No differences between genotypes in the preferred medium gamma phase (p > 0.05). G Same as (C) for medium gamma oscillations. Theta: NWT-D1 = 214, NWT-D2 = 197, NKO-D1 = 199, NKO-D2 = 187, SGamma: NWT-D1 = 89, NWT-D2 = 51, NKO-D1 = 65, NKO-D2 = 47, SGamma: NWT-D1 = 78, NWT-D2 = 63, NKO-D1 = 60, NKO-D2 = 56. Pale yellow and pale purple backgrounds denote data from Day 1 and Day 2, respectively

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