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Fig. 2 | Molecular Autism

Fig. 2

From: Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

Fig. 2

Example firing rate maps and activity measures. Example firing rate maps from 4 WT (left) and 4 Fmr1−/y (right) CA1 pyramidal cells, each from a different animal. Top: Spike waveforms (black lines) from the tetrode channel with the highest amplitude waveforms across the 6 recording sessions. Red solid lines indicate the mean waveforms. Dotted red lines indicate the standard error. Middle: movement trajectory (black path) and superimposed action potentials of the cell (red dots) across the 6 sessions in the novel environment. Mean session firing rates (Hz) and burst probability (Burst P) are stated above each plot. Bottom: Smoothed firing rate maps of the same cell, with warmer colours indicating higher firing rates. Spatial information (bits/spk), sparsity, place field size (cm2) and percentage of visited bins in which the cells fired (% Active) for each session is stated above the firing rate map. Pale yellow and pale purple backgrounds denote data from Day 1 and Day 2, respectively

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