Altered frontal connectivity as a mechanism for executive function deficits in fragile X syndrome

Table 4 Significant regression models in FXS

Frequency band	KiTAP variable	Effect	Estimate	SE	DF	t	p
Gamma (Poisson)	Distractor error	Intercept	0.870	0.254	50	3.42	0.001
		Sex (F)	0.092	0.081	50	1.13	0.263
		Nonverbal Z-score	− 0.088	0.018	50	− 4.82	< 0.0001
		Age	− 0.003	0.004	50	− 0.80	0.426
		dWPLI Left frontal	15.562	2.251	50	6.91	< 0.0001
Gamma (Log normal)	Flexibility median RT	Intercept	8.173	0.488	43	16.77	< 0.0001
		Sex (F)	0.134	0.172	43	0.78	0.440
		Nonverbal Z-score	− 0.059	0.0338	43	− 1.75	0.086
		Age	− 0.019	0.007	43	− 2.69	0.010
		dWPLI Left frontal	− 11.218	4.544	43	− 2.47	0.018
Gamma (female only)	Flexibility error	Intercept	16.171	6.813	19	2.36	0.029
		Nonverbal Z-score	− 0.966	0.392	19	− 2.46	0.024
		Age	− 0.128	0.086	19	− 1.48	0.156
		dWPLI Left frontal	174.93	78.772	19	2.22	0.039
		dWPLI Cross-hemi	− 294.98	108.36	19	− 2.72	0.014
Alpha	Flexibility error	Intercept	14.46	3.252	43	4.44	< 0.0001
		Sex (F)	− 1.025	1.259	43	− 0.81	0.420
		Nonverbal Z-score	− 1.204	0.260	43	− 4.64	< 0.0001
		Age	− 0.053	0.053	43	− 1.00	0.321
		dWPLI Right prefrontal	− 60.564	18.245	43	− 3.32	0.002
Alpha (Poisson)	Distractor error	Intercept	3.463	0.222	50	15.61	< 0.0001
		Sex (F)	0.242	0.081	50	2.98	0.005
		Nonverbal Z-score	− 0.082	0.019	50	− 4.37	< 0.0001
		Age	0.0002	0.004	50	0.06	0.954
		dWPLI Right frontal	− 8.893	1.610	50	− 5.52	< 0.0001

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