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Fig. 4 | Molecular Autism

Fig. 4

From: Imbalance of flight–freeze responses and their cellular correlates in the Nlgn3−/y rat model of autism

Fig. 4

Nlgn3−/y rats display increased jumping behaviour in response to electrical shocks. A Schematic of the shock-ramp test protocol and typical order of responses seen. B Lowest shock amplitude required to elicit a response of any kind was not different between WT and Nlgn3−/y rats (p = 0.13, unpaired t-test, WT n = 11, KO n = 14). C Shock amplitude required to elicit backpedalling response was not different between WT and Nlgn3−/y rats (p = 0.26, unpaired t-test, WT n = 11, KO n = 14). D Nlgn3−/y rats display significantly more jumps in response to increasing intensity electrical foot-shocks (p = 0.0081, F(1, 23) = 8.39, repeated measures two-way ANOVA, WT n = 11, KO n = 14). Data represented as mean ± SEM, clear dots represent individual animals

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