Fig. 3

Nlgn3^−/y rats show faster learning and prolonged avoidance of the shock-zone in an active place avoidance task. A Schematic depicting habituation day and first training session of active place avoidance task (no lid present on arena). B 88.9% Nlgn3^−/y and 11.1% WT rats jumped out of the arena following 0.2 mA foot-shocks given over the 8 training trials training (p = 0.0034, Fisher’s exact test, WT n = 9, KO n = 9). Training trial number on which each rat escaped is displayed on right. C Schematic of the active place avoidance task, with added lid. D Representative track  plots for WT and Nlgn3^-/y rats in trials 1 and 8 of training sessions 1 and 2. E, F Nlgn3^-/y rats enter the shock-zone significantly fewer times during training session 1 (p = 0.0045, F_{(1, 21)} = 10.09, repeated measures two-way ANOVA, WT n = 12, KO n = 11), and spend significantly less time in the shock-zone (p = 0.027, F_{(1, 21)} = 5.68 repeated measures two-way ANOVA, WT n = 12, KO n = 11). G, H Nlgn3^-/y rats enter the shock-zone significantly fewer times during training session 2 (p = 0.044, F_{(1, 21)} = 4.60, repeated measures two-way ANOVA, WT n = 12, KO n = 11), and spend significantly less time in the shock-zone (p = 0.025, F_{(1, 21)} = 5.80, repeated measures two-way ANOVA, WT n = 12, KO n = 11). I Representative track plots for WT and Nlgn3^−/y rats in the probe trial. J, K Nlgn3^-/y rats enter the shock-zone significantly fewer times during the probe trial (p = 0.0039, F_{(1, 21)} = 10.51, repeated measures two-way ANOVA, WT n = 12, KO n = 11), and spend significantly less time in the shock-zone (p = 0.045, F_{(1, 21)} = 4.53, repeated measures two-way ANOVA, WT n = 12, KO n = 11). Data represented as mean ± SEM