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Fig. 4 | Molecular Autism

Fig. 4

From: White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities

Fig. 4

Correlations between fixel metrics and Autism Diagnostic Observation Schedule 2 Calibrated Severity Score (ADOS-CSS), derived from the dimensional analysis of the entire ASD cohort (i.e., ASD-Whole). Upper block – Panels a–c show the fixels where the correlation of log(FC) and ADOS-CSS reach statistical significance from the coronal, sagittal, and transverse view, respectively. A zoomed image of c is displayed with the green dashed border. Fixels are colored in red for P-FWE < 0.05; fixels colored in blue indicate P-FWE < 0.1 and are used to assist identification of the associated brain structure. d The scatter plot shows the mean log(FC) residuals on the vertical axis and the normalized ADOS-CSS residuals on the horizontal axis. Only all fixels that reach P-FWE < 0.05 are considered in the plot. Lower block – e shows an axial slice of the group average FOD image. f shows the FA map of the same slice of (e). g is a zoomed region of (e), showing the microstructural organization of axonal fibers around the significant fixels within the cerebellum, which could not be reliably studied using tensor-based voxel-based analysis. Acronyms – R Right, L Left, P-FWE Family-wise error corrected P value

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