Fig. 3

Correlations between fixel metrics and Global Executive Composite (GEC), derived from the dimensional analysis of the entire study cohort. Upper block – Panels a–c show the fixels where the correlation of FD and GEC × diagnosis interactions reach statistical significance from the coronal, sagittal, and transverse view, respectively. A zoomed image of c is displayed with the green dashed border. Fixels are colored in red for P-FWE < 0.05; fixels colored in blue indicate P-FWE < 0.1 and are used to assist identification of the associated brain structure. d The scatter plot shows the residuals of the mean FD on the vertical axis and of the normalized GEC on the horizontal axis. The lines are the regression lines fitting the data, with the orange being for TDC and the green being for ASD. Only all fixels that reach P-FWE < 0.05 are considered in the plot. Lower block – The format in Panels e–h is the same as the upper block, except that the results are obtained from the analysis of FDC and GEC. Acronyms – R Right, L Left, P-FWE Family-wise error corrected P value