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Fig. 7 | Molecular Autism

Fig. 7

From: Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice

Fig. 7

Effects of Myt1l haploinsufficiency on locomotor activity and habituation learning in the activity box. A–A′ Locomotor activity is increased in Myt1l+/- mice. Repeated-measures ANOVA with the between-subject factors genotype (G) and sex (S) and the within-subject factor time (T). T: F29,1508 = 3.848; p < .001; TxG: F29,1508 = 1.819; p = .005; TxS: F29,1508 = 1.634; p = .018; G: F1,52 = 8.682; p = .005; S: F1,52 = 11.948; p = .001; all other p > 0.050. B–B′ Rearing behavior is increased in Myt1l+/- mice. Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor time (T). T: F29,1508 = 2.760; p < .001; G: F1,52 = 17.237; p < .001; GxS: F1,52 = 5.395; p = .024; all other p > 0.050. C–C′ Locomotor activity remains high in Myt1l+/- mice during the second exposure to the activity box. Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor time (T). TxS: F29,1508 = 1.853; p = .004; G: F1,52 = 15.266; p < .001; S: F1,52 = 22.731; p < .001; GxS: F1,52 = 9.918; p = .003; all other p > 0.050. D–D′ Rearing behavior remains high in Myt1l+/- mice during the second exposure to the activity box. Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor time (T). T: F29,1508 = 4.570; p < .001; TxS: F29,1508 = 2.086; p = .001; G: F1,52 = 11.525; p < .001; all other p > 0.050. All data are means ± SEM, combined across males and females; *p < 0.05; **p < 0.01; ***p < 0.001; #p < 0.05 versus day 1

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