Fig. 6
From: Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice
Effects of Myt1l haploinsufficiency on body weight gain and body temperature after weaning. A Body weight gain is increased in male and female Myt1l+/- mice. Representative picture of two females from the same litter (left: Myt1l+/+ littermate control, right: Myt1l+/- mouse). B Body weight gain after weaning measured at PND 378 (relative to PND 25). ANOVA with the between-subject factors genotype (G) and sex (S), followed by unpaired t tests when appropriate. G: F1,50 = 26.381; p < .001; S: F1,50 = 5.532; p = .023; GxS: F1,50 = 4.054; p = .049. C Body weight gain trajectories after weaning. Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor age (A), followed by individual ANOVAs when appropriate. A: F16,800 = 596.784; p < .001; AxG: F16,800 = 13.965; p < .001; AxS: F16,800 = 6.314; p < .001; AxGxS: F16,800 = 3.621; p < .001, G: F1,50 = 13.428; p = .001; S: F1,50 = 37.161; p < .001; all other p > 0.050. D Body temperature is not altered in male and female Myt1l+/- mice. ANOVA with the between-subject factors genotype (G) and sex (S); all p values > 0.050. Of note, N = 2 male Myt1l+/+ littermate control mice died a natural death between months 11 and 13 without evidence of injuries from fighting and were excluded from the body weight gain and body temperature analyses. All data are means ± SEM, combined across males and females if not otherwise indicated; *p < 0.05; **p < 0.01; ***p < 0.001