Fig. 10
From: Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice
Effects of Myt1l haploinsufficiency on spatial learning and reversal learning. A Spatial learning and reversal learning in the Barnes maze is intact in Myt1l+/- mice. B Intact spatial learning and reversal learning is reflected in a decrease in the latency needed to reach the target hole and the reversal target hole, respectively. Repeated-measures ANOVA with the between-subject factors genotype (G) and sex (S) and the within-subject factor trial (T). For spatial learning, T: F15,780 = 41.186; p < .001; S: F1,52 = 6.936; p = .011; all other p > 0.050. For reversal learning, T: F15,780 = 28.583; p < .001; S: F1,52 = 4.138; p = .047; all other p > 0.050. C Affinity for the target hole during spatial learning is unchanged in Myt1l+/- mice. ANOVA with the between-subject factors genotype (G) and sex (S); all p > 0.050. D Intact spatial learning in Myt1l+/- mice is also reflected in a clear preference for visiting the target hole during the last spatial learning day. Gray highlighting indicates target. Repeated-measures ANOVA with the between-subject factors genotype (G) and sex (S) and the within-subject factor preference (P). P: F8,416 = 70.310; p < .001; all other p > 0.050. E Primary errors during spatial learning are unchanged in Myt1l+/- mice. ANOVA with the between-subject factors genotype (G) and sex (S); all p > 0.050. F Affinity for the reversal target hole is slightly reduced in Myt1l+/- mice. ANOVA with the between-subject factors genotype (G) and sex (S); all p > 0.050. Paired t test for comparing reversal target hole (triangle) and initial target hole (circle); Myt1l+/- mice: t29 = 1.615; p = .117; Myt1l+/+ mice: t25 = 2.222; p = .036. G, H Despite a clear preference for the initial target hole, intact reversal learning in Myt1l+/- mice is also reflected in the rapid development of a secondary preference for visiting the reversal target hole during the first reversal learning day. Gray highlighting indicates target. Repeated-measures ANOVA with the between-subject factors genotype (G) and sex (S) and the within-subject factor preference (P). For the initial target hole, P: F8,416 = 72.597; p < .001; all other p > 0.050. For the reversal target hole, P: F8,416 = 9.625; p < .001; PxS: F8,416 = 3.657; p < .001; all other p > 0.050. I Primary errors during reversal learning are unchanged in Myt1l+/- mice. ANOVA with the between-subject factors genotype (G) and sex (S); all p > 0.050. All data are means ± SEM, combined across males and females; *p < 0.05; **p < 0.01; ***p < 0.001. #p < 0.05 versus 4.5s chance level or adjacent holes to target