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Fig. 2 | Molecular Autism

Fig. 2

From: Deep phenotyping reveals movement phenotypes in mouse neurodevelopmental models

Fig. 2

Spatial–temporal structure of C57BL/6J male mice behavior in the open field. a Behavioral cluster frequency across mouse models on Day 1. (left) Heatmap of the total behavioral occupancy of each behavioral cluster; rows are individual animals and columns are behavioral clusters. All rows within the 100-cluster matrix sum to one and describe behavior used over 20 min. Clusters are ordered by median centroid speed for each of the eight behavioral classes (bottom). (right) Heatmap of the behavioral occupancy for each of the eight behavioral classes. b Total occupancy of behavioral classes in a 20-min recording quantified by human annotators and by the algorithm. c Log ratio differences for all 8 behavioral classes between selected groups. The error bars show the bootstrapped 95% confidence interval (N = 5000, percentile bootstrap). d The spatial distribution is shown for each of the eight behavioral classes. e Behavioral usage for each of eight coarse categories plotted for C57BL/6J male mice for each of four observation days. All individuals are shown as points, colored traces correspond to the median fraction of time spent in the behavior for each day. f The usage of grooming and locomotion behaviors during the 20-min observation period for Days 1 and 4. Shaded regions represent the 95% confidence interval (left). The mean usage (right) for each of eight behavioral classes is shown for Days 1 and 4

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