Table 2 Demographic and clinical profiles across subgroups
|  | Subtype 1 (n = 115) | Subtype 2 (n = 106) | HC (n = 257) | p value a | p value b | p value c |
|---|---|---|---|---|---|---|
Age | 15.3 ± 6.8 | 15.5 ± 6.0 | 14.2 ± 6.1 | 0.825 | 0.104 | 0.056 |
Type (A/AS/P/NA) | 58/11/5/41 | 58/12/4/32 | – | 0.926 | – | – |
IQ | ||||||
 FIQ | 111 ± 15.3 | 104 ± 13.5 | 114 ± 12.1 |  < 0.001 | 0.182 |  < 0.001 |
 VIQ | 109 ± 15.7 | 107 ± 16.1 | 114 ± 13.0 | 0.545 | 0.006 | 0.001 |
 PIQ | 112 ± 14.3 | 103 ± 13.7 | 111 ± 13.0 |  < 0.001 | 0.714 |  < 0.001 |
Site | 14/17/21/10/10/18/25 | 11/11/14/10/12/20/28 | 22/66/41/21/25/35/47 | 0.791 | – | – |
ADOS | ||||||
 Total | 11.8 ± 3.6 | 10.7 ± 3.3 | 1.3 ± 1.7 | 0.041 |  < 0.001 |  < 0.001 |
 Comm | 3.7 ± 1.6 | 3.5 ± 1.3 | 0.6 ± 1.0 | 0.469 |  < 0.001 |  < 0.001 |
 Social | 8.1 ± 2.5 | 7.4 ± 2.6 | 0.7 ± 1.0 | 0.111 |  < 0.001 |  < 0.001 |
 RRB | 2.1 ± 1.8 | 1.7 ± 1.5 | 0.1 ± 0.5 | 0.090 |  < 0.001 |  < 0.001 |
 Severity | 7.7 ± 1.5 | 6.4 ± 2.4 | – | 0.004 | – | – |
ADI-R | ||||||
 Social | 20.5 ± 5.0 | 19.5 ± 5.2 | – | 0.209 | – | – |
 Verbal | 16.3 ± 4.3 | 15.4 ± 4.6 | – | 0.219 | – | – |
 RRB | 6.1 ± 2.5 | 6.4 ± 2.5 | – | 0.517 | – | – |
SRS | ||||||
 Total | 96.1 ± 32.8 | 90.5 ± 32.0 | 17.7 ± 12.9 | 0.342 |  < 0.001 |  < 0.001 |
 Aware | 13.2 ± 4.0 | 11.7 ± 3.4 | 4.3 ± 2.7 | 0.096 |  < 0.001 |  < 0.001 |
 Cognit | 16.6 ± 6.2 | 14.9 ± 5.8 | 2.8 ± 2.7 | 0.223 |  < 0.001 |  < 0.001 |
 Comm | 33.8 ± 10.1 | 28.9 ± 11.8 | 5.7 ± 5.1 | 0.058 |  < 0.001 |  < 0.001 |
 Motiva | 15.5 ± 5.8 | 12.9 ± 7.3 | 3.7 ± 3.1 | 0.095 |  < 0.001 |  < 0.001 |
 Manner | 18.9 ± 6.3 | 17.3 ± 7.1 | 1.9 ± 2.5 | 0.316 |  < 0.001 |  < 0.001 |