Table 3 Summary statistics for clinical outcomes
From: A proof-of-concept study of growth hormone in children with Phelan–McDermid syndrome
Measurea | Variable | Baseline Mean (SD) | Week 12 Mean (SD) | p value | Wilcoxon r effect |
|---|---|---|---|---|---|
ABC | Irritability | 10.31 (7.6) | 4.6 (2.3) | 0.225 | 0.50 |
Social withdrawal | 14.8 (7.4) | 6.2 (3.4) | 0.028 | 0.90 | |
Stereotypy | 8.8 (6.9) | 5.1 (1.8) | 0.249 | 0.47 | |
Hyperactivity | 33.3 (6.2) | 16.5 (7.7) | 0.027 | 0.90 | |
Inappropriate speech | 3.3 (4.3) | 2.3 (3.8) | 0.285 | 0.44 | |
RBS-R | Stereotyped behavior | 4.3 (1.7) | 4.0 (2.4) | 0.577 | 0.23 |
Self-injurious behavior | 0.7 (0.8) | 1.3 (1.8) | 0.157 | 0.58 | |
Compulsive behavior | 2.8 (3.2) | 1.3 (1.6) | 0.083 | 0.71 | |
Ritualistic behavior | 1.2 (1.2) | 0.8 (1.2) | 0.414 | 0.33 | |
Sameness behavior | 2.3 (2.4) | 2.0 (1.7) | 0.680 | 0.17 | |
Restricted behavior | 2.0 (2.2) | 1.2 (1.5) | 0.129 | 0.62 | |
Total | 13.3 (6.1) | 10.7 (3.1) | 0.248 | 0.47 | |
SSP | Tactile | 31.5 (2.1) | 31.7 (2.0) | 1.00 | 0.00 |
Taste/smell | 18.2 (3.6) | 19.4 (1.3) | 0.317 | 0.41 | |
Movement | 13.3 (1.6) | 13.7 (1.8) | 0.157 | 0.58 | |
Sensation | 17.5 (4.8) | 20.0 (2.4) | 0.416 | 0.33 | |
Auditory | 20.0 (1.9) | 22.0 (2.4) | 0.144 | 0.60 | |
Low energy/weak | 16.5 (6.9) | 20.5 (5.2) | 0.141 | 0.60 | |
Visual/auditory | 22.3 (2.3) | 22.7 (1.5) | 0.414 | 0.33 | |
Total | 139.3 | 148.8 | 0.042 | 0.83 | |
CGI | Improvement score | – | 1.7 (0.5) | 0.023 | 0.93 |