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Fig. 5 | Molecular Autism

Fig. 5

From: Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K)

Fig. 5

Genetic deletion of eEF2K rescues autistic-like behavior in Scn1a ± mice.A Significantly increase in repetitive grooming behavior in Scn1a ± mice compared with WT and Scn1a ± eEF2K−/− mice evaluated in terms of time spent in self-grooming over 10 min observation. Data are presented as mean ± SEM. N = 10 per group. Statistical analysis ***p < 0.001 versus corresponding WT; $$p < 0.01 versus corresponding Scn1a ± ; Kruskal–Wallis test, Dunn’s post hoc. B,C Scn1a ± mice do not show anxiety-behavior in elevated plus maze(B) and marble burying (C) test. B Open arm entries (left) and time spend in open arms (right), evaluated in the elevated plus maze test over 5 min. Data are presented as mean ± SEM. N = 10 per group. One-way ANOVA, Tukey’s post hoc. C Number of marbles buried (left) and latency to the first buried (right) evaluated in the marble-burying test over 15 min. Data are presented as mean ± SEM. N = 10 per group. Statistical analysis $p < 0.05 versus corresponding Scn1a ± ; One-way ANOVA, Tukey’s post hoc. D Time spent immobile in tail suspension test do not show depressive-like behaviors in Scn1a ± mice when compared with WT mice. Scn1a ± eEF2K−/− mice show depressive-like behavior when compared with WT and Scn1a ± mice. Data are presented as mean ± SEM. N = 10 per group. Statistical analysis %%%p < 0.001 versus corresponding WT, $$p < 0.01 versus corresponding Scn1a ± ; One-way ANOVA, Tukey’s post hoc

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