Fig. 4
From: How rare and common risk variation jointly affect liability for autism spectrum disorder
Continuous liability model for ASD compared to empirical realization. a Liability is assumed to be normally distributed in the population, and there exists a threshold t of liability beyond which everyone is affected and below which no one is affected. ASD prevalence determines t and the average risk of ASD and unaffected subjects; given an estimate of the relative risk of ASD due to rare damaging variants, the average risk of PDV carriers of these PDVs is also specified. b A portion of A, highlighting the relatively even spacing between its average risks. c The realized average risk of these three groups, as measured by the weighted genomic risk score with their 95% confidence intervals (Fig. 3)