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Fig. 6 | Molecular Autism

Fig. 6

From: Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons

Fig. 6

TCF4 expression during hippocampal development. af Overview images of the hippocampal formation at different developmental stages. TCF4 is expressed throughout pre- and postnatal development of the hippocampus. gi TCF4 expression in the CA1 region of the hippocampus. At E18.5, TCF4 is expressed in radially migrating pyramidal progenitor cells and in the forming pyramidal cell layer. Postnatally, TCF4 is expressed in the pyramidal cell layer and in scattered cells in the stratum oriens and radiatum. jl At E18.5, TCF4 is expressed in dentate progenitor cells that migrate to the subpial zone (primary and secondary matrix) and in the forming pyramidal cell layer of the CA3 region. At postnatal stages P7 and P56, TCF4 is expressed in the pyramidal cell layer and in scattered cells of the strata oriens and radiatum. mo At E18.5, TCF4 is expressed in dentate progenitor cells that accumulate in the hippocampal fissure (tertiary matrix). Postnatally, TCF4 is expressed in the granular cell layer of the dentate gyrus and in individual cells of the hilus. Abbreviations: 1ry, primary matrix; 2ry, secondary matrix; 3ry, tertiary matrix; ANE, ammonic neuroepithelium; CH, cortical hem; DG, dentate gyrus; DNE, dentate neuroepithelium; GCL, granular cell layer; H, hilus; LAC-MOL, stratum lacunosum-moleculare; MOL, molecular layer; OR, stratum oriens; PCL, pyramidal cell layer; RAD, stratum radiatum; SVZ, subventricular zone

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