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Fig. 5 | Molecular Autism

Fig. 5

From: Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons

Fig. 5

TCF4 expression during corticogenesis. (AF) Heatmap converted TCF4 immunoreactivity at different stages of cortical development. TCF4 is expressed in all layers of the neocortex with particular high intensity in the expanding cortical plate during development (GI”). TCF4 is expressed in Sox2-positive ventricular zone cells (GG”), DCX-positive immature neurons (HH”), and NeuN-positive neurons (II”). TCF4 co-stainings with layer V/VI neuron marker CTIP2 (JJ”) or layer II/III/IV neuron marker Cux1 (K-K”) at P7. TCF4 is expressed in layers II-VI but only individual TCF4-positive cells co-localize with the layer markers. TCF4 is expressed in GAD67-positive interneurons (LL”). Abbreviations: CP, cortical plate; IZ, intermediate zone; MZ, marginal zone; PP, preplate; SP, subplate; SVZ, subventricular zone; VZ, ventricular zone

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