Gene/protein | UniProt accession | Gene fold change | Protein fold change | RTT hit? | Putative function |
---|---|---|---|---|---|
Mecp2/MeCP2 | Q9Z2D6 | − 0.66 | − 10.6 | Yes1, 2 | DNA binding protein; transcriptional regulator |
Rnpep/RNPEP* | Q8VCT3 | − 0.78 | − 3.47 | Yes2 | Peptide catabolic process |
Pdia4/ERp72* | P08003 | − 0.71 | − 2.22 | Yes2,3 | ER protein processing |
Hsph1/HSPH1 | Q61699 | − 0.80 | − 2.13 | Yes4 | Protein chaperone |
Rnpep/RNPEP(Ac)* | Q8VCT3 | − 0.78 | − 2.02 | Yes2 | Peptide catabolic process |
Aldh1a1/ALDH1A1* | P24549 | − 0.67 | − 1.95 | Yes2 | Retinal dehydrogenase |
Slc9a3r1/NHERF1(P)* | P70441 | − 0.74 | − 1.79 | Yes3 | Scaffold protein |
Ugt8a/UGT8 | Q64676 | − 0.79 | − 1.76 | --- | Sphingolipid metabolism |
Qdpr/QDPR (or DHPR)* | Q8BVI4 | − 0.74 | − 1.68 | Yes2 | Monoamine metabolism (tetrahydrobiopterin biosynthesis) |
Ugp2/UGP2* | Q91ZJ5 | − 0.73 | − 1.67 | Yes2 | Glycogen synthesis |
Car2/Ca2 | P00920 | − 0.72 | − 1.61 | --- | Reversible hydration of carbon dioxide |
Grm3/mGluR3* | Q9QYS2 | − 0.63 | − 1.6 | Yes2 | Protein coupled glutamate receptor |
Ephx2/EPHX2* | P34914 | − 0.71 | − 1.59 | Yes2 | Cholesterol synthesis |
Hpcal4/HPCAL4* | Q8BGZ1 | − 0.69 | − 1.51 | Yes2,3 | Calcium binding |
Spr/SPR | Q64105 | − 0.77 | − 1.47 | --- | Monoamine metabolism (tetrahydrobiopterin metabolic process) |
Sash1/SASH1 | P59808 | − 0.82 | − 1.44 | --- | p38 MAPK and NIK/NF-kappaB signaling |
Calr/CRT* | P14211 | − 0.80 | − 1.43 | Yes3 | ER calcium-binding protein |
Aacs/AACS* | Q9D2R0 | − 0.79 | − 1.37 | Yes2 | Fatty acid and lipid metabolism |
S1pr1/S1P1 | O08530 | − 0.78 | − 1.28 | --- | Cell-cell adhesion |
Slc9a3r1/NHERF1(Ac)* | P70441 | − 0.74 | − 1.24 | Yes3 | Scaffold protein |
Nova1/NOVA1 | Q9JKN6 | 1.26 | 1.28 | --- | RNA/mRNA-binding protein |
Slc24a4/Nckx4* | Q8CGQ8 | 1.58 | 1.3 | Yes3 | K+-dependent Na+/Ca2+ exchanger |
Kcnab3/Kvβ3.1 | P97382 | 1.27 | 1.43 | --- | Voltage gated K+ channel |
Me3/NADP-ME3 | Q8BMF3 | 1.28 | 1.46 | --- | Mitochondrial NADP(+)-dependent malic enzyme |
Tfrc/TfR | Q62351 | 1.32 | 1.48 | --- | Cell surface receptor required for iron uptake |
Dgkg/DGKγ* | Q91WG7 | 1.42 | 1.51 | Yes2,3 | Lipid metabolism |
Prkcg/PKCγ(P)* | P63318 | − 0.82 | 1.66 | Yes3 | Protein kinase; LTP |
Rasgrf1/RasGRF1 | P27671 | 1.32 | 1.68 | --- | Stimulates the dissociation of GDP from RAS protein |
Zmat4/ZMAT4* | Q8BZ94 | 1.50 | 1.88 | Yes3 | DNA/RNA and p53 binding |
Myo1b/Myo1b* | P46735 | 1.32 | 2.02 | Yes2,3 | Actin binding; calmodulin binding |
Fkbp5/FKBP5 | Q64378 | 1.81 | 2.02 | Yes2–6 | Immunoregulation; protein trafficking |
Wipf3/WIPF3 | P0C7L0 | 1.23 | 2.26 | --- | Cytoskeleton organization |
Itih3/ITI-HC3 | Q61704 | 1.52 | 2.37 | --- | Anchor protein between hyaluronan and matrix proteins |
Gfra1/GDNFRα1* | P97785 | 1.26 | 2.64 | Yes2,3 | RET and RAF/MAP kinase signaling cascade |
Sun2/SUN2* | Q8BJS4 | 1.42 | 2.86 | Yes3 | Nuclear envelope protein |