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Table 3 Differentially abundant proteins associated with metabolism and S-adenosylmethionine-dependent methylation

From: RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome

Gene name

Protein description

FC

p-value

General putative function

Metabolism

Lss

Lanosterol synthase

8.1

0.016

Cholesterol synthesis

Aacs*

Acetoacetyl-CoA synthetase

− 1.4

0.059

Ketone body utilization

Acadvl

Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1.6

0.045

Fatty acid oxidation

Ugp2 #

UTP-glucose-1-phosphate uridylyltransferase

− 1.7

0.011

Glycogen metabolism

Acot7

Cytosolic acyl coenzyme A thioester hydrolase

− 1.3

0.087

Fatty Acyl-CoA biosynthesis

Monoamine metabolism

Qdpr #

Dihydropteridine reductase

− 1.7

0.029

Tetrahydrobiopterin synthesis

Spr*

Sepiapterin reductase

− 1.5

0.083

Tetrahydrobiopterin synthesis

Maoa

Amine oxidase [flavin-containing] A

1.4

0.096

Degradation of monoamines

S-adenosylmethionine-dependent methylation

Gamt

Guanidinoacetate N -methyltransferase

− 1.7

0.089

Creatine synthesis

Srm

Spermidine synthase (SPDSY)

− 1.5

0.024

Polyamine synthesis

Mthfd1l

Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1.7

0.054

Folate synthesis

  1. Significant proteins (p < 0.1) are listed by gene name (first column), followed by the full protein name (second column). For each protein, the fold change (“FC”) and p-value is provided (third and fourth columns, respectively), along with a brief description regarding the putative function of that protein (“General Putative Function”). Information regarding the putative function of each protein was obtained from the UniProtKB/Swiss-Prot database [131]. Gene names with an asterisk (“*”) indicates that the corresponding gene was also identified as significantly, differentially expressed (DE) in the transcriptome by a q < 0.05, while genes with a pound sign (“#”) indicate that gene was identified as DE in the transcriptome by a q < 0.01. Bold proteins indicate that the respective protein has been previously identified as a RTT hit and/or MeCP2 interacting protein