Fig. 5

Transcriptome and proteome general cellular and molecular pathways in Mecp2 ^Jae/y cortex. Selected biological pathways that are both shared and unique to the transcriptome (R) and proteome (P) data sets are grouped by broad categories associated with general cellular/molecular function: (a) cell cycle, (b) cellular components/structure/general function, and (c) lipids and metabolism. Respective pathways are plotted by −Log₁₀ p-value, where a value of 1.3 or greater represents a p-value of at least p < 0.05; non-significant (NS) pathways are denoted in white. The direction of gene (gray bars) and/or protein (black bars) expression changes associated with each respective pathway are represented as a percent expression to the right of the heat map, where a value greater than 0 indicates increased expression and a value less than 0 indicates decreased expression. The percent expression was calculated by taking the number of genes/proteins with significant increased or decreased expression divided by the total sum of significant genes/proteins assigned to the respective pathway. Note in part B, the abbreviation “AC” in the “G-protein signaling, AC inhibiting pathway” stands for “adenylate cyclase.” For a comprehensive list of all pathways and associated significant genes/proteins identified in both the transcriptome and proteome data sets, see Additional file 10