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Fig. 2 | Molecular Autism

Fig. 2

From: RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome

Fig. 2

Cell type-specific gene expression correlation. a. Mecp2 Jae/y cortex significant DE genes compared to top 500 CNS cell type-specific genes based on the Zhang et al. study [69], which is also provided as a public database. Each pie slice lists the number of DE genes associated with each CNS cell type. b. Fold change expression and gene size correlation in the Mecp2 Jae/y transcriptome. Significant DE genes were plotted by Log2 fold change (FC) expression (y-axis) and gene size (x-axis; in units of kilobase (kb)) according to their respective CNS cell type distribution (based on part A). Expression and gene size correlations were also examined as a whole (bottom scatter plot in black). This relationship is also represented to the right of each scatter plot based on the number of short (defined as being less than 100 kb; gray) and long (defined as being greater than 100 kb; turquoise) genes that are either repressed (i.e., decreased expression) or activated (i.e., increased expression) in the Mecp2 Jae/y cortex

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