Fig. 6

Modified dynamics of social preference in BTBR mice. a Plot of mean investigation time (measured within 20-s bins) across the SP test for male BTBR mice (n = 8) using meshed chambers. b Mean (+SEM) investigation time averaged across the first (left) and last (right) 2 min of the SP test, showing a significant preference only during the early 2 min (p < 0.05 paired-test after Bonferroni correction). c Transitions, represented by blue dots, between stimuli during the SP test. Each line represents one BTBR mouse, and the red line represents the mean of all mice averaged within 20-s bins. d A comparison of mean number of transitions for the first and last 2 min of the SP test, between BTBR and C57BL/6J male mice (p < 0.05, post hoc t test following a main effect). e Distributions of mean total investigation time (+SEM) according to bout duration, for social and object stimuli during the SP test performed by BTBR male mice. f–j As in a–e, respectively, for the SNP test. ***p < 0.001, *p < 0.05