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Table 2 Comparison of DEGs with genes activated in M1 and M2 macrophages

From: Transcriptome analysis of microglia in a mouse model of Rett syndrome: differential expression of genes associated with microglia/macrophage activation and cellular stress

Mecp2 DEGs

M1/M2 expression

Shared genes

p value

5 week (n = 464)

M1 down

28

1.83E−04

M1 up

28

1.34E−05

M2 down

13

3.21E−02

M2 up

34

1.86E−12

24 week (n = 79)

M1 down

8

2.10E−03

M1 up

6

1.44E−02

M2 down

7

2.68E−04

M2 up

8

7.90E−05

  1. DEGs in 5- and 24-week microglia identified in this study were compared with genes activated to produce M1 and M2 macrophages from a baseline state (M0) in mouse [55]. The p values for the gene overlaps were determined by Fisher’s exact test