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Table 3 Summary of findings

From: Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures

 

Differentially expressed genes in Fmr1KO vs WT (disease genes)

Culture

Brain

Hippocampus

Cortex

Hippocampus

Cortex

Number of differentially expressed genes

2648

3372

726

866

Distance between KO and WT clusters on PCA (PC1/PC2)

3.73/0.7

3.31/3.20

0.99/0.6

0.39/0.32

Pathway enrichment

Neuronal processes

Immune processes

Human development

Early (H0 cluster)

Early (C0 cluster)

Later (H1 cluster)

Later (C2 cluster)

Up-regulated

Up-regulated

Down- and up- regulated

Up-regulated

SFARI human genes

Significantly enriched in down-regulated genes

Significantly enriched in down-regulated genes

Not significant

Not significant

MGI mouse genes associated with behavioral/neurological phenotype

Significantly enriched in down-regulated genes

Significantly enriched in down-regulated genes

Not significant

Not significant

FMRP targets

Significantly enriched in down-regulated genes

Significantly enriched in down- and up- regulated genes

Not significant

Not significant