Differentially expressed genes in Fmr1KO vs WT (disease genes) | ||||
---|---|---|---|---|
Culture | Brain | |||
Hippocampus | Cortex | Hippocampus | Cortex | |
Number of differentially expressed genes | 2648 | 3372 | 726 | 866 |
Distance between KO and WT clusters on PCA (PC1/PC2) | 3.73/0.7 | 3.31/3.20 | 0.99/0.6 | 0.39/0.32 |
Pathway enrichment | Neuronal processes | Immune processes | ||
Human development | Early (H0 cluster) | Early (C0 cluster) | Later (H1 cluster) | Later (C2 cluster) |
Up-regulated | Up-regulated | Down- and up- regulated | Up-regulated | |
SFARI human genes | Significantly enriched in down-regulated genes | Significantly enriched in down-regulated genes | Not significant | Not significant |
MGI mouse genes associated with behavioral/neurological phenotype | Significantly enriched in down-regulated genes | Significantly enriched in down-regulated genes | Not significant | Not significant |
FMRP targets | Significantly enriched in down-regulated genes | Significantly enriched in down- and up- regulated genes | Not significant | Not significant |