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Figure 3 | Molecular Autism

Figure 3

From: The female protective effect in autism spectrum disorder is not mediated by a single genetic locus

Figure 3

Identification of chromosome X SNPs that escape X-inactivation for tier 1 analysis. This Circos plot shows the length of chromosome X proceeding clockwise with position 0 on the short arm at twelve o’clock. Adjacent to the chromosome position, the innermost ring indicates chromosome banding by the depth of shading; two opposing black arrows indicate the centromere. Regions of chromosome Y homology are shown in purple in the middle ring; SNPs in these regions were excluded from the tier 1 analysis leaving the SNPs unique to chromosome X indicated in green. The outermost ring shows SNP density based on the genotyping array (see ‘Methods’ section) by the height of the bars. Regions that are inactivated on one copy of chromosome X are shown in gray [32] and SNPs in these regions were excluded from the tier 1 analysis, leaving only SNPs that escape X-inactivation, shown in red (Additional file 2: Table S4). Of the 6,955 SNPs on chromosome X, 451 (6.5%) were included in the tier 1 analysis.

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