Table 2 Efficacy table

PDDBI (negative change is an improvement)

   Autism composite

−4.5 (−8.5; −0.6)

−6.4 (−10.2; −2.7)

1.9 (−3.3;7.0)

0.5

  Sensory perception

−2.0 (−5.0; 1.1)

−3.7 (−6.7; −0.6)

1.7 (−2.4;5.9)

0.4

  Social pragmatic

−0.9 (−5.4; 3.5)

−4.3 (−8.6; 0.1)

3.3 (−2.7;9.3)

0.3

  Semantic pragmatic

−0.4 (−5.1; 4.2)

−1.7 (−6.3; 2.9)

1.2 (−5.2;7.6)

0.7

  Social approach^a

−3.3 (−7.4; 0.8)

−1.8 (−5.6; 2.0)

−1.5 (−6.9;3.9)

0.6

  Expressive language^a

−3.5 (−7.3; 0.2)

−1.5 (−5.0; 2.1)

−2.1 (−7.1;3.0)

0.4

  Ritualism/Resistance to change

−3.8 (−6.8; −0.9)

−6.4 (−9.3; −3.5)

2.6 (−1.5;6.6)

0.2

BASC (negative change is an improvement)

  Internalizing

2.2 (−2.1; 6.6)

−2.6 (−6.9; 1.7)

4.8 (−1.0;10.6)

0.1

   Externalizing

3.2 (−0.5; 6.9)

−3.0 (−6.6; 0.6)

6.2 (1.3;11.2)

0.02 ^a

  Functional communication^a

−0.3 (−3.9; 3.3)

−4.3 (−7.8; −0.8)

4.0 (−0.9;8.9)

0.1

  Social^a

−1.2 (−4.2; 1.9)

−4.6 (−7.5; −1.7)

3.4 (−0.6;7.4)

0.1

VABS (positive change is an improvement)

   Adaptive functioning composite

2.8 (0.2; 5.3)

−0.2 (−2.6; 2.2)

3.0 (−0.4;6.4)

0.09

  Motor

0.4 (−4.5; 5.4)

−1.9 (−6.6; 2.9)

2.3 (−4.5;9.1)

0.5

  Social

−0.3 (−3.1; 2.5)

0.8 (−1.8; 3.4)

−1.1 (−4.8;2.6)

0.6

  Communication

1.6 (−1.5; 4.7)

0.9 (−2.0; 3.9)

0.6 (−3.5;4.8)

0.8

  Daily living

5.5 (0.9; 10.0)

−0.7 (−5.0; 3.6)

6.2 (0.01;12.3)

0.05

PLS (positive change is an improvement)

   Total language score

0.7 (−2.7; 4.1)

−0.6 (−3.7; 2.6)

1.3 (−3.1;5.7)

0.6