Feature | Abnormality in Fragile X males vs. FVB controls | Response to antipurinergic therapy |
---|---|---|
Social preference | Decreased | Normalized (P <0.05) |
Social novelty | Decreased | Normalized (P <0.05) |
T-maze spontaneous alternation | Decreased | Normalized (P <0.001) |
Marble burying | Decreased | Normalized (P <0.05) |
Core body temperature | Decreased | Normalized (P <0.001) |
Acoustic startle | Decreased [sic] | Unchanged (P = ns) |
Metabolomics (60 pathways measured) | 20 of 60 pathways disturbed | 33 metabolites increased and 25 decreased of 58 changed |
Synaptosomal structure by electron microscopy | Fragile and malformed post-synaptic densities; Accumulation of electron dense matrix material | Improved |
Synaptosomal proteins (54 interrogated) | N/A | 17 proteins were changed (for example, decreased PI3/GSK3β, GluR1, C1q, and APP; increased PPARβ/δ) |
Locomotor activity - total distance (hyperactivity), center exploration, holepokes, rearing | None | N/A |