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Table 2 Adverse events

From: A pilot controlled trial of insulin-like growth factor-1 in children with Phelan-McDermid syndrome

Adverse events

IGF-1

Placebo

Constipation

4

3

Sedation

1

0

Decreased appetite

2

3

Periobital/facial swelling

1

0

Diarrhea

1

2

URTIa

5

5

Sleep Disturbance

7

2

Increased appetite

4

0

Mood changes/irritability

4

2

Increased thirst

1

0

Increased phlegm

1

0

Teeth grinding

1

0

Cough

1

2

Hand flapping

1

0

Increased bowel movements

1

0

Increased chewing/biting

1

0

Decreased visual acuity

1

0

Lethargy/decreased energy

1

1

Cooler body temperature/sweating

1

0

Runny nose/congestion

1

1

Gait changes/fell

1

2

Stomach virus

1

1

Anxiety

0

2

Increased urine frequency

2

0

Fever

3

3

Increased energy

1

0

Gagging

1

0

Increased thirst

0

1

Conjunctivitis

1

0

Erythema/swollen eyes

1

0

Vomiting

1

1

Rash

3

0

Nose swelling

1

0

Warmer body temperature

1

0

Hair loss

1

0

Increased aggression

1

0

Hypoglycemiab

7

3

  1. aURTI = upper respiratory tract infection. bHypoglycemia was defined by glucose < 50 mg/dL and occurred in 5/9 patients while on IGF-1 and in 2/9 patients while on placebo.