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Table 2 SRM-MS testing of targeted candidate proteins in post mortem prefrontal cortex and cerebellum from autism patients compared to matched controls

From: Proteomic analysis of post mortem brain tissue from autism patients: evidence for opposite changes in prefrontal cortex and cerebellum in synaptic connectivity-related proteins

   

Prefrontal cortex

Cerebellum

   

Prefrontal cortex

Pathways

Gene

Protein name

ratio

P-value

Pathways

Gene

Protein name

ratio

Cell adhesion

RELN

Reelin

ND

ND

Cell adhesion

RELN

Reelin

ND

Astrocyte

GFAP

Glial fibrillary acidic protein

1.02

0.7399

0.7968

1.14

1.8E-05a

7.42E-5

VIME

Vimentin

0.69

2.8E-5a

0.0002

0.56

1 < E-10a

1 < E-9

Energy

CKB

Creatine kinase B-type

1.73

1.3E-9a

1.82E-8

0.92

0.2605

0.3777

Myelin

MAG

Myelin-associated glycoprotein

0.76

0.0087a

0.0272

1.30

0.0016a

0.0042

MBP

Myelin basic protein

0.85

0.1440

0.2373

1.41

0.0003a

0.0009

MOG

Myelin-oligodendrocyte glycoprotein

0.81

0.0567

0.1222

1.37

0.0002a

0.0006

PLP1

Myelin proteolipid protein

0.82

0.0143a

0.0400

1.37

2.8E-10a

2.69E-9

Synaptic vesicle

DNM2

Dynamin-2

1.05

0.7811

0.8024

0.87

0.2910

0.4018

STX1A

Syntaxin-1A

1.07

0.2086

0.3165

0.88

0.0102a

0.0227

STXBP1

Syntaxin-binding protein 1

1.28

0.1002

0.1753

0.97

0.8031

0.8626

SYN2

Synapsin-2

1.29

0.0486a

0.1135

1.04

0.6499

0.7539

SYT1

Synaptotagmin-1

1.06

0.4092

0.5456

0.87

0.0165a

0.0342

PACSIN1

Protein kinase C casein kinase substrate 1

0.96

0.4540

0.5778

0.84

8.1E-5a

0.0003

  1. ND = not detected; asignificant P-value.
  2. Indicated are the themes, protein name, the ratio (autism/control), the P-value and the Q-value. Grey shading indicates the proteins with a significant P-value or Q-value and a ratio of >10%.