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Table 4 Summary of significant sex-diagnosis interactions of serum molecules measured by LC-MS E profiling

From: Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome

    

Males

Females

Code

Protein

Interaction

FDR

Ratio

P-value

Ratio

P-value

RGPD4

RANBP2-like and GRIP domain containing 5

0.015

0.723

0.89

0.016

1.07

0.893

ARMC3

Armadillo repeat containing 3

0.002

0.291

0.88

0.183

1.29

0.001

PTPA

PP 2A activator, reg subunit 4

0.038

0.723

0.97

0.681

1.23

0.001

TLE1

Transducin-like enhancer of split 1

0.049

0.723

0.90

0.394

1.22

0.026

CLC4K

CD207 molecule, langerin

0.017

0.723

0.96

0.720

1.20

<0.001

GLCE

Glucuronic acid epimerase

0.017

0.723

0.88

0.231

1.19

0.018

APOC2

Apolipoprotein C2

0.005

0.522

0.92

0.254

1.19

0.001

ZC3HE

Zinc finger CCCH-type containing 14

0.039

0.723

0.97

0.383

1.16

0.020

FETUB

Fetuin B

0.035

0.723

0.96

0.572

1.15

0.004

RN149

Ring finger protein 149

0.044

0.723

1.02

0.588

1.14

0.042

TRIPB

Thyroid hormone receptor interactor 11

0.012

0.723

0.94

0.610

1.13

0.027

APOE

Apolipoprotein E

0.030

0.723

0.99

0.851

1.11

<0.001

MRRP1

RNA G9 methyltransferase domain cont 1

0.044

0.723

1.06

0.592

0.78

0.035

  1. Indicated are the P-values and FDR (false discovery rate) of the interactions and the separate ratio (AS/control; calculated using geometric means) changes with P-values in males in females. Values in bold font indicate significant differences between AS and typical individuals by sex.