| Age (years) |
---|
Variables | 8 | 11 | 14 | 17 |
---|
SCDC score description |
Median (SD) [range] | 2 (3.71) [0 to 24] | 1 (3.51) [0 to 24] | 1 (3.60) [0 to 24] | 1 (3.79) [0 to 24] |
Age, years (SD) | 7.65 (0.14) | 10.72 (0.13) | 13.90 (0.15) | 16.84 (0.36) |
Males (%) | 51.2% | 50.3% | 50.0% | 48.4% |
N
Total
a
| 5,628 | 5,533 | 5,129 | 4,229 |
SCDC GCTA heritabilityb |
h2 (SE) | 0.24 (0.07) | 0.16 (0.07) | 0.08 (0.07) | 0.45 (0.08) |
LRT (df) | 14.26 (1) | 6.33 (1) | 1.38 (1) | 33.69 (1) |
P-value | 8.0 × 10−5 | 5.9 × 10−3 | 0.12 | 3.2 × 10−9 |
N
GCTA
c
| 5,204 | 5,121 | 4,797 | 4,026 |
- Phenotype description and GCTA within ALSPAC; GCTA, Genome-wide Complex Trait Analysis; LRT, Likelihood ratio test; SCDC, Social Communication Disorder Checklist; ALSPAC, Avon Longitudinal Study of Parents and Children; aIndividuals with genotypic and phenotypic data. bGCTA heritability estimates based on rank-transformed SCDC scores (adjusted for age and sex and the two most significant ancestry-informative principal components). cIndividuals subjected to GCTA, differences compared with the total sample (N
Total
) are due to the exclusion of individuals with relatedness ≥2.5% in GCTA.