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Table 1 Phenotype description and Genome-wide Complex Trait Analysis

From: Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence

 

Age (years)

Variables

8

11

14

17

SCDC score description

Median (SD) [range]

2 (3.71) [0 to 24]

1 (3.51) [0 to 24]

1 (3.60) [0 to 24]

1 (3.79) [0 to 24]

Age, years (SD)

7.65 (0.14)

10.72 (0.13)

13.90 (0.15)

16.84 (0.36)

Males (%)

51.2%

50.3%

50.0%

48.4%

N Total a

5,628

5,533

5,129

4,229

SCDC GCTA heritabilityb

h2 (SE)

0.24 (0.07)

0.16 (0.07)

0.08 (0.07)

0.45 (0.08)

LRT (df)

14.26 (1)

6.33 (1)

1.38 (1)

33.69 (1)

P-value

8.0 × 10−5

5.9 × 10−3

0.12

3.2 × 10−9

N GCTA c

5,204

5,121

4,797

4,026

  1. Phenotype description and GCTA within ALSPAC; GCTA, Genome-wide Complex Trait Analysis; LRT, Likelihood ratio test; SCDC, Social Communication Disorder Checklist; ALSPAC, Avon Longitudinal Study of Parents and Children; aIndividuals with genotypic and phenotypic data. bGCTA heritability estimates based on rank-transformed SCDC scores (adjusted for age and sex and the two most significant ancestry-informative principal components). cIndividuals subjected to GCTA, differences compared with the total sample (N Total ) are due to the exclusion of individuals with relatedness ≥2.5% in GCTA.