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Table 1 Summary of significant and suggestive linkage peaks from AGRE samples

From: Replication of linkage at chromosome 20p13 and identification of suggestive sex-differential risk loci for autism spectrum disorder

Discovery sample

Combined sample (Stage 1 + Stage 2)

Source

Number of families

Subgroup

Locus*

Peak LOD

Number of families

Peak LOD

Peak P-value

Peak SNP

Liu et al. (2001) [26]

110

ALL

5p13.1

2.55

1008

0.99

0.0163

rs6884342

110

ALL

Xq26.1

2.56

1008

1.12

0.0116

rs12557711

Yonan et al. (2003) [34]

345

ALL

5p13.1

2.54

1008

0.99

0.0163

rs6884342

345

ALL

11p13-11.2

2.24

1008

0.92

0.0199

rs2984699

345

ALL

17q11.2

2.83

1008

0.53

0.0592

rs1382779

Stone et al. (2004) [28]

148

MO

17q11

4.3

602

0.42

0.0834

rs4795708

109

FC

4q32.3-35.1

2.7

406

1.10

0.0121

rs1717072

Cantor et al. (2005) [25]

196

MO

17q21

3.6

602

0.47

0.0706

rs1877032

McCauley et al. (2005) [27]

158 (85 AGRE)

ALL

3p25.3

2.22

1008

0.04

0.3344

rs1400207

Szatmari et al. (2007) [32]

741 (211 AGRE)

MO

5q12

2.31

602

1.42

5.34e-3

rs706725

741 (211 AGRE)

MO

9q33.3

2.36

602

1.47

4.64e-3

rs204169

1181 (387 AGRE)

ALL

11p12

2.77

1008

0.92

0.0199

rs2984699

440 (176 AGRE)

FC

11p12

2.86

406

0.38

0.0925

rs404977

Weiss et al. (2009) [33]

904 (753 AGRE)

ALL

6q27

2.94

1008

2.50†

3.43e-4

rs6931082

904 (753 AGRE)

ALL

20p13

3.81

1008

3.02†

9.55e-5

rs6139007

Current study Stage 1 sample

487

MO

1p31.3

2.98

602

2.55†

3.05e-4

rs7521242

 

847

ALL

4q13.1

2.30

1008

2.14

8.37e-4

rs1483288

 

487

MO

4q26

2.41

602

1.28

7.60e-3

rs2196712

 

847

ALL

6q27

3.22

1008

2.50†

3.43e-4

rs6931082

 

487

MO

6q27

2.86

602

2.07

1.02e-3

rs960145

 

314

FC

8p21.2

2.67

406

1.42

5.25e-3

rs7001120

 

847

ALL

8p21.2

2.55

1008

2.18

7.60e-4

rs13257637

 

314

FC

8p12

2.37

406

1.34

6.51e-3

rs2976525

 

847

ALL

8q13.2

2.50

1008

2.82†

1.58e-4

rs4738003

  1. *Refer to Additional file 3: Table S2 for locus details, including boundaries and peak markers.
  2. Bold type indicates logarithm of odds (LOD) scores passing genome-wide significance thresholds of LOD ≥3.6 for discovery studies,
  3. †LOD scores passing suggestive linkage thresholds of LOD ≥2.2 in the combined sample extension study. AGRE, Autism Genetics Resource Exchange; ALL, all families; FC, female-containing; MO, male-only; SNP, single nucleotide polymorphism.
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Molecular Autism

ISSN: 2040-2392