Table 2 Correlation of Simons Foundation and Autism Research Initiative (SFARI) database genes with published transcriptome studies in Autism Spectrum Disorder (ASD) brain and our study
Cerebellum | # SFARI genes | % enrichment | P value | Gene names |
|---|---|---|---|---|
This study (3 En2-/-, 3 WT) | 21 | 2.79% | 4.98E-01 | Ada, Ahi1 , Cacna1g , Cdh10, Eml1, Erbb4, Glo1, Gnas, Grm5, Itgb7, Kdm5c, Kit, Nrp2, Nrxn3, Park2, Pinx1, Plcb1, Rb1cc1, Rpp25, Stk39, Th |
Voineagu et al.[9] (11 autism, 10 controls) | 16 | 4.75% | 3.43E-02 (*) | AHI1 , ANK3, CACNA1G , CBS, EN2 , EPHB6, FAT1, FOXP1,GAP43, GRIN2A, HSD11B1, NLGN3, NTNG1, RAB11FIP5, SLC30A5, UBE3A |
Purcell et al.[39] (9 autism, 9 controls) | 1 | 3.33% | 5.85E-01 | CNR1 |
Limbic regions | # SFARI genes | % enrichment | P value | Gene names |
This study (3 En2-/-, 3 WT) | 33 | 4.24% | 2.65E-02 (*) | Aff4, Atp2b2 , Baiap2, Camta1, Dab1, Dctn5, Dlg4, Egr2, Eif4ebp2 , Ep400, Foxp1, Gabra4, Gnas, Gsk3b, Gtf2i, Kit, Klc2, Lrrc1, Nrcam, Ntng1, Ntrk3 , Park2, Plcb1, Prkcb , Rpp25 , Sbf1, Scn1a, Scn8a, Syn1, Syne1, Thra, Ube2h , Ubl7 |
Voineagu et al.[9] (13 autism, 13 controls) | 36 | 3.70% | 1.04E-01 | AHI1 , APBA2, ATP2B2 , ATRNL1, AUTS2, BCL2, BTAF1, CADM1, CD99L2, DNM1L, DPP10, EIF4EBP2 , FAT1, GRIN2A, ICA1, MAOA, MSN , NTRK3 , PCDH9, PPFIA1, PRKCB , PTCHD1, RAB11FIP5, RGS7, RPP25 , SLC16A3, SLC25A12, SLC9A9, STXBP1, SYT17, TOMM20, TSC2, TUBGCP5, UBE2H , UBR5, UPF3B |
Garbett et al.[40] (6 autism, 6 controls) | 4 | 3.05% | 5.52E-01 | AHI1 , MSN , SDC2, SLC9A9 |