Table 1 Enrichment of autism spectrum disorder (ASD)-related genes in En2 -/- cerebellum and hippocampus differentially expressed genes
(a) Cerebellum | |||
|---|---|---|---|
Gene Symbol | Gene Name | P value | Fold change |
Ada | adenosine deaminase | 3.50E-03 | 1.705 |
Ahi1 | Abelson helper integration site 1 | 4.70E-03 | 1.690 |
Cacna1g | calcium channel, voltage-dependent, T type, alpha 1G subunit | 8.20E-03 | 0.670 |
Cdh10 | cadherin 10 | 4.40E-03 | 1.662 |
Eml1 | echinoderm microtubule associated protein like 1 | 2.80E-03 | 0.581 |
Erbb4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | 9.90E-03 | 0.653 |
Glo1 | glyoxalase 1 | 6.00E-03 | 0.625 |
Gnas | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus | 5.60E-03 | 1.565 |
Grm5 | glutamate receptor, metabotropic 5 | 3.70E-03 | 1.656 |
Itgb7 | integrin beta 7 | 1.00E-04 | 0.453 |
Kdm5c | lysine (K)-specific demethylase 5C | 8.50E-03 | 0.660 |
Kit | kit oncogene | 3.00E-03 | 0.591 |
Nrp2 | neuropilin 2 | 0.00 | 2.503 |
Nrxn3 | neurexin III | 1.80E-03 | 1.843 |
Park2 | Parkinson disease (autosomal recessive, juvenile) 2, parkin | 5.20E-03 | 1.723 |
Pinx1 | PIN2/TERF1 interacting, telomerase inhibitor 1 | 1.00E-03 | 1.871 |
Plcb1 | phospholipase C, beta 1 | 3.60E-03 | 1.677 |
Rb1cc1 | RB1-inducible coiled-coil 1 | 6.90E-03 | 1.635 |
Rpp25 | ribonuclease P 25 subunit (human) | 8.00E-03 | 0.619 |
Stk39 | serine/threonine kinase 39, STE20/SPS1 homolog (yeast) | 9.40E-03 | 1.548 |
Th | tyrosine hydroxylase | 7.90E-03 | 1.564 |
(b) Hippocampus | |||
Gene Symbol | Gene Name | P value | Fold change |
Aff4 | AF4/FMR2 family, member 4 | 1.30E-03 | 4.490 |
Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | 2.80E-03 | 0.544 |
Baiap2 | brain-specific angiogenesis inhibitor 1-associated protein 2 | 8.00E-04 | 0.478 |
Camta1 | calmodulin binding transcription activator 1 | 4.40E-03 | 0.561 |
Dab1 | disabled homolog 1 (Drosophila) | 4.10E-03 | 0.552 |
Dctn5 | dynactin 5 | 4.10E-03 | 1.733 |
Dlg4 | discs, large homolog 4 (Drosophila) | 0.00 | 0.346 |
Egr2 | early growth response 2 | 7.00E-04 | 2.099 |
Eif4ebp2 | eukaryotic translation initiation factor 4E binding protein 2 | 3.90E-03 | 0.551 |
Ep400 | E1A binding protein p400 | 2.00E-04 | 2.361 |
Foxp1 | forkhead box P1 | 3.00E-04 | 0.425 |
Gabra4 | gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 | 4.00E-04 | 2.151 |
Gnas | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus | 3.90E-03 | 0.555 |
Gsk3b | glycogen synthase kinase 3 beta | 3.50E-03 | 0.541 |
Gtf2i | general transcription factor II I | 3.80E-03 | 0.552 |
Kit | kit oncogene | 2.00E-04 | 0.417 |
Klc2 | kinesin light chain 2 | 4.80E-03 | 0.565 |
Lrrc1 | leucine rich repeat containing 1 | 4.20E-03 | 1.742 |
Nrcam | neuron-glia-CAM-related cell adhesion molecule | 3.10E-03 | 1.777 |
Ntng1 | netrin G1 | 1.90E-03 | 1.842 |
Ntrk3 | neurotrophic tyrosine kinase, receptor, type 3 | 1.00E-04 | 0.426 |
Park2 | Parkinson disease (autosomal recessive, juvenile) 2, parkin | 1.00E-04 | 2.402 |
Plcb1 | phospholipase C, beta 1 | 8.00E-04 | 0.487 |
Prkcb | protein kinase C, beta | 8.00E-04 | 0.490 |
Rpp25 | ribonuclease P 25 subunit (human) | 1.10E-03 | 0.487 |
Sbf1 | SET binding factor 1 | 4.40E-03 | 0.562 |
Scn1a | sodium channel, voltage-gated, type I, alpha | 1.00E-04 | 0.410 |
Scn8a | sodium channel, voltage-gated, type VIII, alpha | 1.00E-04 | 0.414 |
Syn1 | synapsin I | 5.00E-04 | 0.469 |
Syne1 | synaptic nuclear envelope 1 | 4.80E-03 | 0.562 |
Thra | thyroid hormone receptor alpha | 1.00E-04 | 0.419 |
Ube2h | ubiquitin-conjugating enzyme E2H | 4.00E-03 | 0.559 |
Ubl7 | ubiquitin-like 7 (bone marrow stromal cell-derived) | 3.70E-03 | 0.557 |