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Table 4 Canonical pathways in NextBio that were significantly enriched following ASD gene-targeted shRNA constructs, but not affected by luciferase shRNA

From: Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action

 

ASD gene count

Fmr1

Mecp2

Mef2a

Mef2d

Nlgn1

Nlgn3

Pten

Shank3

Biogroup

 

Up

Down

Up

Down

Up

Down

Up

down

Up

Down

Up

Down

Up

Down

Up

Down

TrkA receptor

8

 

2

 

4

 

2

 

2

 

2

 

3

3

  

2

Erythropoietin-mediated neuroprotection through NFKB

7

3

2

 

3

 

3

 

1

 

2

 

1

3

   

PGC1A pathway

7

   

8

 

5

 

7

 

3

 

4

 

9

 

4

Long-term potentiation

7

8

  

18

 

5

 

15

3

    

16

 

6

Cell adhesion molecules (CAMs)

7

  

10

14

 

8

 

13

 

8

 

11

13

12

 

10

G2 and M phases

7

 

1

 

1

 

1

1

1

 

1

 

2

3

   

P53 HYPOXIA pathway

7

 

3

 

3

 

3

 

3

 

2

 

3

6

   

Biosynthesis of steroids

6

 

8

 

5

   

3

2

  

5

 

4

  

Arginine and proline metabolism

6

 

8

 

9

1

  

8

   

8

5

   

Antigen processing and presentation

6

   

9

 

3

 

6

 

3

 

10

   

4

BAD pathway

6

 

3

   

3

 

4

2

 

2

    

2

Neuroregulin receptor degredation protein-1 controls ERBB3 receptor recycling

6

  

1

 

1

 

1

 

1

 

1

   

1

 

Eicosanoid synthesis

6

     

1

 

1

 

1

 

1

3

  

2

Phosphatidylinositol signaling system

5

10

  

17

     

6

 

11

 

10

  

Vitamin B6 metabolism

5

1

  

3

  

1

1

  

1

2

 

1

 Â