Skip to main content
Figure 3 | Molecular Autism

Figure 3

From: Platelets of mice heterozygous for neurobeachin, a candidate gene for autism spectrum disorder, display protein changes related to aberrant protein kinase A activity

Figure 3

Normal expression of actin and the proteins involved in dense granule formation and secretion in platelets of Nbea+/-mice. (A) Western blot analysis detected no changes in the total actin levels in platelets of Nbea+/- mice compared to Nbea+/+ mice. Actin expression was normalized to the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) content and the expression in platelets of wild-type mice was set at 100% (n = 4/genotype). (B) The total amount of Munc13-4, Rab27b and Calmodulin was unaltered in platelets of Nbea+/- mice. Protein levels were normalized to actin and the expression level in platelets of Nbea+/+ mice was set at 100% (n = 4 samples/genotype).

Back to article page