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Figure 4 | Molecular Autism

Figure 4

From: Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice

Figure 4

Assays of the serotonin system in B6 SERT Ala56 knock-in mice. A) Whole blood serotonin levels (mean, standard error of the mean) in adult male wildtype littermate control (G/G, n = 6) and homozygous SERT Ala56 (A/A, n = 6) mice; B) Whole blood serotonin levels in male pups at postnatal day 7 (n = 12 per genotype); C) Synaptosome uptake of 20 nM 3H5-HT during a 5-minute assay at 37°C, (n = 6 per genotype, with 3 replicates for each subject); D) Synaptosome uptake of 100 nM 3H5-HT during a 5-minute assay at 37°C (n = 6 per genotype, with 3 replicates for each subject); E) Head twitch response to injection of the 5-HT2 agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) during a 15-minute observation period (n = 12 per genotype); F) Decrease in rectal temperature from baseline in response to injection of the mixed 5-HT1A/7 agonist 8-OH-DPAT (n = 10 per genotype).

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