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Figure 2 | Molecular Autism

Figure 2

From: Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice

Figure 2

Social behaviors and pup ultrasonic vocalizations in male B6 SERT Ala56 knock-in mice. A) Time (mean, standard error of the mean) spent in the social stimulus chamber (novel mouse), center chamber, or inanimate stimulus chamber (novel object) in the three-chamber sociability test for wildtype littermate controls (G/G, n = 20), heterozygous (A/G, n = 16), and homozygous (A/A, n = 20) SERT Ala56 mice; B) Time spent within 1 cm of the social stimulus or inanimate stimulus in the three-chamber sociability test; C) Total number of wins (frontward exit) for pairings of wildtype littermate controls (G/G) and homozygous SERT Ala56/Ala56 (A/A) mice in the tube test confrontation; D) Total number of wins for heterozygous (A/G) versus homozygous SERT Ala56 (A/A) mice when paired in the tube test; E) Total number of wins for wildtype (G/G) versus heterozygous SERT Ala56 (A/G) mice when paired in the tube test; F) Latency to attack a wildtype 129S4 intruder mouse introduced into the cage of a resident subject mouse who had been singly housed for 7 days (n = 16 per genotype); G) Pup vocalizations upon separation from the dam for 5 min at postnatal day 7 for wildtype littermate controls (G/G, n = 36), heterozygous (A/G, n = 65), and homozygous SERT Ala56 (A/A, n = 33) mouse pups. *P <0.05.

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