Figure 4

Differential expression of SYNGAP1 -AS in the postmortem brain of patients affected by ASD compared to age-matched controls. Strand-specific qRT-PCR analysis of SYNGAP1-AS expression in: (a) Prefrontal cortex (PFC, n = 9), (b) Superior temporal gyrus (STG, n = 9) and (c) Cerebellum (CER, n = 7) of ASD patients and age-matched non-ASD individuals. *P <0.05, **P <0.01, Student’s t-test. (d) Linear regression plot demonstrating negative correlation of SYNGAP1-AS with SYNGAP1 gene expression in the prefrontal cortex of control individuals. R = −0.7047, p <0.05, Pearson Correlation. SYNGAP1-AS expression is normalized to PGK1.